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CHILD Study Fast Facts and Knowledge Translation Initiatives

  1. 3624 families have been recruited which means over 9,600 people are participating in this study.
  2. All babies have been born and 3,313 home visits have been conducted. Over 2,000 1 year assessments iare complete and 3-year visits are now beginning.
  3. The cohort population is ethnically, environmentally, socioeconomically and culturally diverse; over 25% of parents report non-Caucasian ethnicity, reflecting the general structure of the Canadian population.
  4. The maternal prevalences of current asthma symptoms (15%) and atopy (56% have positive skin tests) are essentially the same as those in the Canadian population, indicating data will be generalizable.
  5. Over 300,000 aliquots of biological samples have been placed in liquid nitrogen storage, including cord blood from over 75% of the births, over 90% of all urine, stool, and nasal samples from the children, and 85% of possible breast milk samples. Blood samples were obtained from 66% of 1 year olds seen.

Publications, Abstract and Conference Presentations

PEER-REVIEWED PAPERS (PDF attached)

  1. Azad, M.B, Konya, T,. Maughan, H., Guttman, D.S., Field, C.J., Sears, M.R., Becker, A.B., Scott, J.A., Kozyrskyj, A.L. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy, Asthma & Clinical Immunology 2013, 9:15 doi:10.1186/1710-1492-9-15 (PDF)
  2. Azad MB, Konya T, Koster B, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj and the CHILD Study investigators. Gut microbiota in Canadian infants: profiles by birth mode and diet. Can Med Assn J 2013. (PDF)

PEER-REVIEWED PAPERS

  1. (P01) Epidemiology of asthma: risk factors for development. Subbarao P, Becker A, Brook JR, Daley D, Mandhane PJ, Miller GE, Turvey SE, Sears MR, on behalf of the CHILD Study Investigators. Expert Review Clin Immunol 2009; 5: 77-95.
  2. (P02) Asthma: epidemiology, etiology and risk factors. Subbarao P, Mandhane PJ, Sears MR CMAJ 2009; 181: E181-190.
  3. (P03) Handling ethical, legal and social issues in birth cohort studies involving genetic research: responses from studies in six countries. Ries NM, LeGrandeur J, Caulfield. TBMC Medical Ethics 2010; 11: 4
  4. (P04) Exposure assessment in cohort studies of childhood asthma. Arrandale VH, Brauer M, Brook JR, Brunekreef B, Gold DR, London SJ, Miller JD, Ozkaynak H, Ries NM, Sears MR, Silverman FS, Takaro TK. Environ Health Perspect. 2011; 119: 591-7.
  5. (P5) Balancing efficiency and the protection of research participants: Canadian allergy/asthma researchers' perspectives on the ethics review of multi-site health research. Master Z, Ries NM, Caulfield T. J Clinic Res Bioeth 2011; 2: 5.
  6. (P06) Perinatal programming of asthma: the role of gut microbiota. Azad MB, Kozyrskyj AL. Clin Dev Immunol 2012; 2012:932072 doi: 10.1155/2012/932072
  7. (P07) Age and height dependence of lung clearance index and functional residual capacity. Lum S, Stocks J, Stanojevic S, Wade A, Robinson P, Gustafsson P, Brown M, Aurora P, Subbarao P, Hoo AF, Sonnappa S. Eur Respir J 2013; 41: 1371-7
  8. (P08) Gut microbiota diversity and atopic disease: does breastfeeding play a role? Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL, on behalf of the Canadian Healthy Infant Longitudinal Development Study Investigators. J Allergy Clin Immunol 2013; 131: 247-8
  9. (P09) Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, on behalf of the CHILD Study Investigators. Can Med Assn J 2013; 185:385-94
  10. (P10) A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust. Sbihi H, Brook JR, Allen RW, Curran JH, Dell S, Mandhane P, Scott JA, Sears MR, Subbarao P, Takaro TK, Turvey SE, Wheeler AJ, Brauer M. Environ Health 2013; 12:48
  11. (P11) Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL and CHILD Study Investigators. Allergy Asthma Clin Immunol 2013; 9: 15.
  12. (P12) Associations between bacterial communities of house dust and infant gut. Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA, the CHILD Study Investigators. Environ Res 2014; 131: 25-30
  13. (P13) A review of the key issues associated with the commercialization of biobanks. Caulfield T, Burningham S, Joly Y, Master Z, Shabani M, Borry P, Becker A, Burgess M, Calder K, Critchley C, Edwards K, Fullerton SM, Gottweis H, Hyde-Lay R, Illes J, Isasi R, Kato K, Kaye J, Knoppers B, Lynch J, McGuire A, Meslin E, Nicol D, O'Doherty K, Ogbogu U, Otlowski M, Pullman D, Ries N, Scott C, Sears M, Wallace H, Zawati MH. J Law Biosciences 2014; 94-110. Doi. 10.1093/jlb/1st004
  14. (P14) Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based cross sectional study. Persaud RP, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL and the CHILD Study investigators. J Matern Fetal Neonatal Med, on line August 2014
  15. (P15 ) You are how your recruit: a cohort and randomized controlled trial of recruitment strategies. Maghera A, Kahlke P, Lau A, Zeng Y, Hoskins C, Corbett T, Manca D, Lacaze-Masmonteil T, Hemmings D, Mandhane P. BMC Med Res Methodol 2014 Sep 27; 14:111. doi: 10.1186/1471-2288-14-111
  16. (P16) The Canadian Healthy Infant Longitudinal Development Birth Cohort Study: Biological Samples and Biobanking. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD; CHILD Study Investigators. Paediatr Perinat Epidemiol. 2015;29:84-92
  17. (P17) Perinatal exposure to traffic-related air pollution and development of atopy in a Canadian birth cohort study. Sbihi H, Allen RW, Becker A, Brook J, Mandhane P, Scott JA, Sears MR, Subbarao O, Takaro TK, Turvey SE, Brauer M. Environ Health Perspect; on line March 2015 doi/10.1289/eph.1408700
  18. (P18) The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P, Turvey SE, Wheeler AJ, Zeng L, Sears MR, Brook JR and the CHILD study investigators. Journal of Exposure Science and Environmental Epidemiology advance online publication 25 March 2015; doi: 10.1038/jes.2015.7
  19. (P19) Infant gut microbiota and food sensitization: associations in the first year of life. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, Hayglass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL and the CHILD study investigators. Clin Exp Allergy 2015;45:632-43

NON- PEER REVIEWED PUBLICATIONS

  1. (NP01) CHILDhood influences. Sears MR. International Innovation 2013; April: 118-120

THESES

  1. (TH01) Shu H. Phthalate exposure in a Canadian birth cohort at three months of age: exposure sources and the influence of socioeconomic status. MSc thesis, Simon Fraser University, 2012
  2. (TH2) McConkey CE. Per- and polyfluorinated compounds in blood and their impact on respiratory problems in young children in Winnipeg, Manitoba MSc thesis, University of Manitoba, 2012
  3. (TH3) McLean K. Comparison of questionnaire responses with biomarkers of environmental tobacco smoke exposure in a Canadian birth cohort at three months of age. MPH thesis, Simon Fraser University, 2013
  4. (TH4) Lau AA. Sleep and sleep disordered breathing in the first year of life: a Canadian birth cohort study MSc thesis, University of Alberta, 2014
  5. (TH5) Kalu R. Maternal overweight prior to pregnancy and its impact on the infant gut microbiome and subsequent child overweight risk. MSc thesis, University of Alberta, 2015

ABSTRACTS – NATIONAL AND INTERNATIONAL MEETINGS

  1. (A1) The Canadian Healthy Infant Longitudinal Development (CHILD) study. Ontario Thoracic Society annual meeting, Toronto 2010. Sears MR. Can Respir J 2010; 17: Suppl A: 36A-37A.
  2. (A2) Lung clearance index as a marker of peripheral airway disease in children under 5 years of age. Brown M, Balkovec S, Keast C, Rampersad N, Grewal R, Ratjen FA, Subbarao P. American Thoracic Society annual meeting 2010. Am J Respir Crit Care Med 2010; 181: A5968.
  3. (A3) Lung clearance index as a marker of peripheral airways disease in children under 5 years of age. Brown M, Balkovec S, Ratjen F, Subbarao P. 5th Annual AllerGen conference, Quebec City. 2010
  4. (A4) A comparison of Manitoba CHILD participants and the general Manitoba population.Protudjer JLP, Luo JC, Becker AB. 5th Annual AllerGen conference, Quebec City. 2010
  5. (A5) Lung clearance index as a marker of early asthma symptoms in infants. Brown M, Balkovec S, Bendiak G, Subbarao P. 5th Annual AllerGen conference, Quebec City. 2010
  6. (A6) Effects of forced expiratory maneuvers and bronchodilator on lung clearance index in infants. Brown M, Jensen R, Balkovec S, Ratjen F, Subbarao P. American Thoracic Society annual meeting, Denver 2011. Am J Respir Crit Care Med 2011; 183: A6311.
  7. (A7) Effects of raised volume rapid thoracic compression on subsequent measurements of infant flow. Thavagnanam S, Brown M, Osman M, Jensen R, Rampersad N, Grewal R, Balkovec S, Ratjen F, Subbarao P. American Thoracic Society annual meeting, Denver 2011. Am J Respir Crit Care Med 2011: 183: A6308.
  8. (A8) Synergy in Microbiota Research (SyMBIOTA). Kozyrskyj AL, Scott JA, Azad MB, Guttman DS, Mandhane PJ, Becker AB, HayGlass KT and the SyMBIOTA Team. International Human Microbiome Congress, Vancouver BC. 2011
  9. (A9) Estimating the variability of endotoxin, (1,3)-?-D-glucan, and hopanes in repeated samples of settled house dust. Sbihi H, Allen R, Takaro T, Brauer M. 6th Annual AllerGen conference, Vancouver. 2011
  10. (A10) Impact of environmental exposures on the bacterial community in the human infant gut: a pilot project. Konya T, Koster B, Becker AB, Mandhane PJ, Befus DA, Kozyrskyj AL, Scott JA. 6th Annual AllerGen conference, Vancouver. 2011
  11. (A11) Synergy in Microbiota Research (SyMBIOTA). Kozyrskyj AL, Scott JA, Azad MB, Guttman DS, Mandane PJ, Becker AB, HayGlass KT and the SyMBIOTA Team. 6th Annual AllerGen conference, Vancouver. 2011
  12. A12 Potential sources of phthalate exposure in the Vancouver CHILD study at three months of age. Shu H, Takaro T, Allen R, Brauer M, Rousseau R, Turvey S. 6th Annual AllerGen conference, Vancouver. 2011
  13. (A13) Exposure assessment methods for the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Takaro T, Ryan A, Scott J, Brauer M, Wheeler AJ, Sears M, Brook JR. 21st Annual International Society of Exposure Science (ISES) Conference, Baltimore. 2011
  14. (A14) Hopanes in settled dust: A novel method to assess exposure to traffic-related air pollution. Sbihi H, Allen R, Brook JR, Curran JH, Dell S, Grgicak-Mannion A, Wheeler AJ, Brauer M. 21st Annual International Society Environmental Sciences (ISES) conference, Baltimore. 2011
  15. (A15)Potential sources of phthalate exposure in the CHILD study pilot cohort at three months of age. Shu H, Takaro T, Allen R, Brauer M, Turvey S, Rousseau R. 21st Annual International Society Environmental Sciences (ISES) conference, Baltimore. 2011
  16. (A16) Breastfeeding, intestinal IgA and Clostridium difficile colonization: implications for atopic disease? Azad MB, Hill AS, Konya T, Koster B, Maughan H, Guttman D, Sears M, Becker AB, Turvey S, Scott JA, Kozyrskyj AL. American Thoracic Society annual meeting 2012. Am J Respir Crit Care Med 2012; 185: A5492.
  17. (A17) Environmental exposures and exhaled nitric oxide at three months of age. Takaro TK, Stanojevic S, Shu H, Brook J, Allen R, Scott J, McLean K, Subbarao P. American Thoracic Society annual meeting 2012. Am J Respir Crit Care Med 2012; 185: A3362.
  18. (A18) The Lung Clearance Index in early life is not independent of body size: Canadian Healthy Infant Longitudinal Development Study. Stanojevic S, Brown M, Ratjen F, Subbarao P. 7th AllerGen Annual Conference, Toronto. 2012
  19. (A19) An exploratory approach to "Total Exposure Assessment" in the CHILD Study; preliminary validation of an environmental exposure index. McLean K, Brook J, Scott J, Sears M, Allen R, Brauer M, Shu H, Subbarao P, Turvey S, Becker A, Mandhane P, Takaro T. 7th AllerGen Annual Conference, Toronto. 2012
  20. (A20) Exclusive breastfeeding protects against Clostridium difficile colonization by promoting lower relative abundance of Lachnospiraceae in gut microbiota: implications for atopic disease? Azad MB, Konya T, Koster B, Maughan H, Guttman D, Sears MR, Becker AB, Scott JA, Kozyrskyj AL and the CHILD Study Investigators. 7th AllerGen Annual Conference, Toronto. First place award 2012
  21. (A21) Is house dust a reservoir for gut bacteria? Konya T, Koster B, Maughan H, Ewaze J, Azad M, Guttman D, Becker AB, Kozyrskyj A, Scott J. 7th AllerGen Annual Conference, Toronto. 2012
  22. (A22) Potential sources of phthalate exposure in the CHILD study at three months of age. Shu H, Zeng L, Allen R, Sears M, Brook J, Scott J, Brauer M, Subbarao PJ, Becker A, Mandhane P, Turvey S, Takaro T. 7th AllerGen Annual Conference, Toronto. 2012
  23. (A23) Evaluation of exhaled nitric oxide measurements in infants at three months and twelve months of age. Rampersad N, Keast C, Stanojevic S, Balkovec S, Jensen R, Kang S, Ratjen F, Subbarao P. 7th AllerGen Annual Conference, Toronto. 2012
  24. (A24) The impact of recruitment methods on CHILD study enrollment. Luo J, Chooniedass R, Kozyrskyj AL, Ramsey CD, Becker AB. 7th AllerGen Annual Conference, Toronto. 2012
  25. (A25) Use of social media in the CHILD study. Unruh C, Chooniedass R, Kozyrskyj AL, Ramsey CD, Becker AB. 7th AllerGen Annual Conference, Toronto. 2012
  26. (A26) Exclusive breastfeeding protects against Clostridium difficile colonization by promoting lower relative abundance of Lachnospiraceae in gut microbiota. Azad MB, Hill AS, Konya T, Koster B, Maughan H, Guttman D, Sears MR, Becker AB, Scott JA, Kozyrskyj AL and the CHILD Study Investigators. Human Microbiome International Conference, Paris, France. 2012
  27. (A27) Phthalate exposure in early life and immune response at one year of age; data from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Takaro T, Shu H, Allen R, Brook JR, McLean K, Scott J, Brauer M, Wheeler AJ, Lefebvre D, Sears M. Conference of ISEE, ISES and ISIAQ, Basel Switzerland 2012
  28. (A28) Examining the utility of hopanes as exposure tracer of traffic-related air pollution. Sbihi H, Allen R, Brook JR, Curran JH, Dell S, Wheeler AJ, Brauer M. UW-UBC-SFU-UVIC annual Occupational Environmental Public Health Conference, Semiahmoo WA 2012
  29. (A29) Introducing the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Takaro T. Canadian Public Health Association Conference, Edmonton. 2012
  30. (A30) Infant gut microbiota and the hygiene hypothesis of allergic disease. Azad MB, Konya T, Koster K, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, the CHILD Study Investigator. Canadian Society Allergy Clinical Immunology, Calgary First place award. 2012 - Allergy, Asthma Clin Immunol 2012; 8 (Suppl 1): A12
  31. (A31) Opportunities and challenges in assessing exposure to traffic related air pollution for birth cohort studies. Sbihi H. School of Population and Public Health/OEH, Vancouver BC 2013
  32. (A32) Atopy at age 1 and traffic-related air pollution: an investigation of exposure measures in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Sbihi H, Allen R, Becker A, Lefebvre D, Mandhane P, Sears M, Subbarao P, Turvey S, Brauer M. Environment and Health Conference of ISEE, ISES and ISIAQ, Basel Switzerland 2013
  33. (A33) The microflora hypothesis of allergic disease: infant gut microbiota profiles according to early-life environmental exposures. Azad MB, Konya T, Koster B, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. American Thoracic Society annual meeting, Philadelphia 2013. Am J Respir Crit Care Med 2013; 187: A2529
  34. (A34) Social media: a tool for retention? Unruh CR, Becker A. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A4
  35. (A35) Attrition in the Canadian Healthy Infant Longitudinal Development (CHILD) study. Venevongsa JC, Chooniedass R, Kozyrskyj AL, Ramsey CD, Becker AB. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A16
  36. (A36) Optimizing subject retention in a longitudinal birth cohort study: lessons learned from the Vancouver site of the CHILD study. Warner L, Mauro MA, Menzies S, Assadian G, Mamonluk R, Lepine C, Turvey SE. Canadian Society Allergy Clinical Immunology, Toronto 2013 Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A20
  37. (A37) Impact of caesarean section delivery and breastfeeding on infant gut microbiota at one year of age. Azad MB, Konya T, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A24
  38. (A38) Impact of perinatal antibiotic exposure on the infant gut microbiota at one year of age. Persaud R, Azad MB, Konya T, Guttman DS, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A31
  39. (A39) Infant gut microbiota and the development of wheeze in early childhood. Salas SM, Azad MB, Konya T, Guttman DS, Becker AB, Sears MR, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A35
  40. (A40) Are known biomarkers for asthma present in early infancy? Boyce MA, Stanejovic S, Kowalik K, Balkovec S, Ratjen F, Sears MR, Subbarao P. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A48
  41. (A41) Phthalate exposures in a Canadian birth cohort at three months of age: the CHILD study. Shu H, Allen R, Bornehag C-G, Brauer M, Brook J, Lanphear B, Sathyanarayana S, Sears M, Zeng L, Takaro T, CHILD Environment Working Group. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A56
  42. (A42) Comparison of questionnaire responses with biomarkers of tobacco smoke exposure in a Canadian birth cohort at three months of age. McLean K, Lanphear B, Wheeler AJ, Brook JR, Scott J, Allen R, Brauer M, Sears M, Subbarao P, Turvey S, Becker A, Mandhane P, Takaro T. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A60
  43. (A43) The impact of the intestinal microbiome on human immune development and atopic disease. Thomas LT, Arrieta M-C, Dimitriu PA, Thorson L, Mohn WW, Finlay BB, Turvey SE. Canadian Society Allergy Clinical Immunology, Toronto 2013. Allergy, Asthma Clin Immunol 2014; 10 (Suppl 1): A63
  44. (A44) Impact of caesarean section delivery and breastfeeding on infant gut microbiota during the first year of life. Azad MB, Konya T, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. World Congress Developmental Origins of Health and Disease, Singapore 2013
  45. (A45) Influence of early life exposures on gut immunity in Canadian infants at 4 months – pilot results from Synergy in Microbiota Research (SyMBIOTA) project. Bridgman S, Azad MB, Hill AS, Konya T, Maughan H, Guttman DS, Sears MR, Becker AB, Survey S, Scott JA, Field CJ, Kozyrskyj AL, and the CHILD Research Team. World Congress Developmental Origins of Health and Disease, Singapore 2013. J Dev Origins Health Disease 2013; 4 (Suppl 2) DOHaD13-1519
  46. (A46) The gut microbiome and the hygiene hypothesis of allergic disease: impact of household pets and siblings on the infant gut microbiome. Azad MB, Konya T, Maughan H, Guttman DS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. Thomas L Petty Aspen Lung Conference, Aspen, CO. 2013. Ann Am Thor Soc 2014; 11: S73
  47. (A47) Phthalate exposures in a Canadian birth cohort at three months of age: the CHILD Study. Shu H, Allen RW, Bornehag C-G, Brauer M, Brook J, Lanphear B, Sathyanarayana S, Sears MR, Zeng L, Takaro TK and the CHILD Environmental Working Group. International Society for Environmental Epidemiology, Brazil (ISEE) 2013 Environmental Health Perspectives
  48. (A48) Longitudinal analysis of DNA methylation as a mediator between environmental exposures and the development of allergies in the CHILD cohort. Jones MJ, Goodman SJ, MacIsaac JL, Turvey S, Subbarao P, Mandhane P, Becker A, Sears M, Kobor MS and the CHILD Cohort Investigators. Keystone Epigenetics meeting, Boston, MA 2014
  49. (A49) Biological embedding via the gut microbiota: impact of caesarean section delivery and breastfeeding on infant gut microbiota during the first year of life. Azad MB, Konya T, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD study Investigators Canadian Institute For Advanced Research (CIFAR) Cell to Society Symposium, Toronto 2014
  50. (A50) Analysis of DNA methylation in the CHILD cohort: epigenetics as a mediator between environmental exposures and childhood allergies. Jones MJ, Goodman SJ, MacIsaac JL, Turvey S, Kobor MS. Canadian Institute For Advanced Research (CIFAR) Cell to Society Symposium, Toronto 2014.
  51. (A51) Breastfeeding, infant gut microbiota, and early childhood overweight: implications for cardiovascular disease. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. CIHR-ICHR Young Investigators Forum, Edmonton 2014.
  52. (A52) Network analysis of the indoor dust microbiome in Winnipeg homes. Konya T, Azad M, Brook J, Takaro TK, Guttman D, Sears M, Becker A, Kozyrskyj A, Scott J and the CHILD Study Investigators. American Society Microbiology, Boston 2014
  53. (A53) Evolution of the infant gut microbiome from 3 to 12 months of age: temporal changes and impact of antibiotic exposure. Azad MB, Konya T, Guttman DS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. American Society Microbiology, Boston 2014
  54. (A54) Breastfeeding, infant gut microbiota, and early childhood overweight. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. Experimental Biology meeting, San Diego 2014. The FASEB Journal 2014; 28 (1) Suppl 637.4
  55. (A55) Environmental exposures and wheeze at three and twelve months of age in the Canadian Healthy Infant Longitudinal Development study (CHILD). Takaro TK, McLean K, Brook JR, Allen R, Scott J, Turvey S, Becker A, Mandhane P, Subbarao P, Sears MR. International Society Environmental Epidemiology 2014
  56. (A56) Recurrent wheezing in infants is associated with greater lung ventilation inhomogeneity than CF or healthy controls. Lu Z, Balkovec S, Gustafsson P, Sears M, Ratjen F, Subbarao P. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189: A5524
  57. (A57) Environmental exposures and wheeze at three and twelve months of age in the Canadian Healthy Infant Longitudinal Development (CHILD) study. Takaro TK, McLean K, Brook JR, Allen R, Scott J, Turvey S, Becker A, Mandhane P, Subbarao P, Sears MR. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189; A2848
  58. (A58) Variation in FeNO values in infants followed in a longitudinal birth cohort study and relationship to clinical and environmental factors. Boyce MA, McLean K, Kowalik K, Lu Z, Balkovec S, Ratjen FA, Sears M, Takaro TK, Subbarao P. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189: A5637
  59. (A59) LCI as a measure for early diagnosis of asthma in children. Dubeau A, Balkovec S, Jensen R, Lu Z, Gustafsson P, Ratjen F, Sears M, Subbarao P. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189; A1028
  60. (A60) The variability of TPEF/TE in naturally sleeping healthy newborns. Kanga N, Gaddipati N, Lau F, Lu Z, Dubeau A, Balkovec S, Keast C, Sears MR, Ratjen F, Subbarao P. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189; A3236
  61. (A61) Risk factors for sleep disordered breathing in the first year of life: a sub-study within the Canadian Healthy Infant Longitudinal Development (CHILD) study. Lau A, Mariasine J, Sears M, Subbarao P, Becker A, Turvey S, Mandhane P. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189: A1805
  62. (A62) Exploring the origins of asthma: development, demographics and early results of the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Subbarao P, Anand SS, Becker AB, Befus AD, Brook JR, HayGlass KT, Kollmann TR, Kozyrskyj AL, Lou WYW, Mandhane PJ, Miller GE, Moraes TJ, Sandford AJ, Scott JA, Takaro TK, Turvey SE, Duncan JD, Lefebvre DL, Sears MR and the CHILD Study Investigators. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189: A4590
  63. (A63) Association of infant gut microbiota at 3 months and atopic sensitization at 1 year. Azad MB, Konya T, Guttman DS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. American Thoracic Society annual meeting, San Diego 2014. Am J Respir Crit Care Med 2014; 189; A6610
  64. (A64) Exploring origins of asthma and allergy: early results from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Sears MR, Subbarao P, Kozyrskyj AL, Azad MB, McLean K, Takaro TK, Anand SS, Becker AB, Befus AD, Brook JR, HayGlass KT, Kollmann TR, Lou WYW, Mandhane PJ, Miller GE, Moraes TJ, Scott JA, Turvey SE, Duncan JD, Lefebvre DL, and the CHILD Study Investigators. European Academy Allergy Clinical Immunology annual meeting, Copenhagen 2014.
  65. (A65) An investigation of traffic-related air pollution exposure measures in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort and the risk for developing allergies in early years. Sbihi H, Allen RW, Becker A, Brook J, Mandhane P, Sears MR, Subbarao P, Turvey SE, Brauer M. International Society Exposure Science (ISES), Cincinnati 2014
  66. (A66) Cluster analysis of Lung Clearance Index and infant phenotypes in the Canadian Healthy Infant Longitudinal Development (CHILD) study. Lu Z, Dubeau A, Balkovec S, Gustafsson P, Sears M, Ratjen F, Lou W, Subbarao P. American Thoracic Society annual meeting 2015
  67. (A67) Association of meconium microbiota and prenatal maternal atopic disorders in pregnancy. Koleva PT, Kim J-S, Guttman DS, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Scott JA, Kozyrskyj AL and the CHILD Study investigators. American Thoracic Society annual meeting 2015
  68. (A68) Early-infancy microbial and metabolic alterations preceding asthma. Arrieta M-C, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Brandt R, Lefebvre DL, Subbarao P, Mandhane P, Becker A, Sears MR, McNagny K, Kollmann T, Mohn WW, the CHILD study investigators, Turvey SE, Finlay BB. Microbiota Keystone Symposium 2015
  69. (A69) Gut microbiota metabolites in term infant at 3 months of age according to breastfeeding status. Bridgman SL, Koleva P, Azad MB, Field CJ, Haqq AM, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, Sears MR, Wishart DS, Kozyrskyj AL and the CHILD study investigators. International Human Microbiome Congress, Luxembourg 2015
  70. (A70) Bacterial composition of the infant gut microbiome is shaped by maternal prenatal weight. Koleva P, Kim J-S, Guttman D, Sears MR, Becker A, Mandhane P, Subbarao P, Turvey S, Scott J, Kozyrskyj A and the CHILD study investigators. International Human Microbiome Congress, Luxembourg 2015.
  71. (A71) Frequent antibiotic treatment impacts early development of gut microbiota in infants. Azad M, Konya T, Guttman D, Becker A, Sears M, Mandhane P, Subbarao P, Turvey S, Scott J, Kozyrskyj A and the CHILD study investigators. International Human Microbiome Congress, Luxembourg 2015
  72. (A72) Epigenetic markers of early life exposures in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Takaro TK, Jones M, Kobor M, Brook J, McLean K, Joffres Y, Allen R, Brauer M, Sears M. International Society for Environmental Epidemiology(ISEE) 2015
  73. (A73) Consumption of artificially-sweetened beverages during pregnancy and the risk of early childhood overweight. Azad MB, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR and the CHILD Study investigators. Canadian Nutrition Society (Winnipeg) 2015
  74. (A74) Breastfeeding and establishment of infant gut microbiota. Koleva P, Konya T, Kim J-S, Guttman DS, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Scott JA, Kozyrskyj AL and the CHILD Study investigators. inFlame 2015
  75. (A75) Early life gut microbial alterations in children diagnosed with asthma by three years of age. Stiemsma LT, Arrieta M-C, Dimitriu PA, Thorson L, Yurist S, Kuzeljevic B, Lefebvre DL, Subbarao P, Mandhane P, Becker A, Sears M, McNagny KM, Kollmann T, the CHILD study investigators, Mohn WW, Finlay BB, Turvey SE. European Respiratory Society, Amsterdam 2015
  76. (A76) Impact of maternal overweight during pregnancy on the newborn gut microbiome. Koleva P, Kim J-S, Guttman DS, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Scott JA, Kozyrskyj AL, and the CHILD Study investigators. Teratology, Montreal 2015
  77. (A77) Impact of pregnancy overweight and depression on the newborn gut microbiome. Koleva PT, Kim J-S, L Bridgman SL, Chow A, Guttman DS, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Scott JA, Kozyrskyj AL, and the CHILD Study Investigators. International DOHaD meeting Cape Town. 2015

Notable Publications

  1. Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL, on behalf of the CHILD Study investigators. Gut microbiota diversity and atopic disease: does breastfeeding play a role. J Allergy Clin Immunol 2012; (Letter to the Editor). Response to "Low diversity of the gut microbiota in infants with atopic eczema." Abrahamsson TR, et al JACI 2012;129:434-40.
  2. Master Z, Ries NM, Caulfield T. Balancing efficiency and the protection of research participants: Canadian allergy/asthma researchers' perspectives on the ethics review of multi-site health research. Clinic Res Bioeth 2011;2:5. A review of ethical challenges to asthma/allergy research including the CHILD Study.Lum S, Stocks J, Stanojevic S, Wade A, Robinson P, Gustafsson P, Brown M, Aurora P, Subbarao P, Hoo A-F, Sonnappa S. Age and height dependence of lung clearance index and functional residual capacity. Eur Respir J 2012. Normal data for infant and childhood lung function including infants from the CHILD study.
  3. Arrandale VH, Brauer M, Brook JR, Brunekreef B, Gold DR, London SJ, Miller JD, Ozkaynak H, Ries NM, Sears MR, Silverman FS, Takaro TK. Exposure assessment in cohort studies of childhood asthma. Environ Health Perspect. 2011;119:591-7. A summary of the Banff 2008 AllerGen-sponsored workshop reviewing the state-of-the-art for measurements of environmental exposures
  4. Ries NM, LeGrandeur J, Caulfield T. Handling ethical, legal and social issues in birth cohort studies involving genetic research: responses from studies in six countries. BMC Medical Ethics 2010;11(1):4
  5. Subbarao P, Mandhane PJ, Sears MR. Asthma: epidemiology, etiology and risk factors. CMAJ 2009;181:E181-190. A short summary of the literature review for the grant application for CHILD re known and possible risk factors, written as the first paper in the CMAJ series on asthma management (updated Canadian guidelines)
  6. Subbarao P, Becker A, Brook JR, Daley D, Mandhane PJ, Miller GE, Turvey SE, Sears MR, on behalf of the CHILD study investigators. Epidemiology of asthma: risk factors for development. Expert Review Clin Immunol 2009;5(1):77-95. An extensively referenced summary of the literature review performed for the CIHR grant application for CHILD discussing known and possible risk factors for development of asthma

SELECTED ABSTRACTS RELATED TO DEVELOPMENT OF ASSESSMENT TOOLS FOR CHILD (reporting mini-CHILD results and CMP methods)

  1. Keast C, Amin R, Balkovec S, Shehnaz D, Rijkers GT, Al-Saleh S, Grasemann H, Dompeling E, Ratjen F, Subbarao P. Non-invasive assessment of airways inflammation in pediatric asthma. Presented at 4th Annual AllerGen Conference, Ottawa, 2009.
  2. Shu H, Takaro T, Allen R, Brauer M, Rousseau R, Turvey S. Potential sources of phthalate exposure in the Vancouver CHILD study at three months of age. Presented 5th Annual AllerGen conference, Quebec City, 2010. Data related to mini-CHILD subjects.
  3. Konya T, Ewaze J, Urch B, Hsa H, Curran J, Speck M, Allen R, Brauer M, Brook J, Diamond M, Evans G, Takara T, Wheeler A, Scott J. Validation of a new wipe method for the collection of indoor dust samples for the characterization of endotoxin and beta-glucan. Presented at 5th AllerGen Annual Conference, Quebec City, 2010. Vacuum dust collection method used in CHILD is described, but data are from mini-CHILD homes.
  4. Chaudhuri S, Diamond M, Allen R, Brauer M, Brook J, Curran J, Diamond M, Evans G, Jiang Z, Konya T, Mykhaylova N, Speck M, Scott J, Shu H, Takaro T, Turvey S, Urch B, Wheeler A. Exploring the linkage between phthalates and asthma by measurement and modeling. Poster presentation at AllerGen 5th Annual Conference, Feb 2010. Presents proposed work for "Toronto Intensive" study of phthalate concentrations and exposure in adults.
  5. Speck M, Allen R, Brauer M, Brook J, Curran J, Diamond M, Evans G, Jiang Z, Konya T, Mykhaylova N, Scott J, Shu H, Takaro T, Turvey S, Urch B, Wheeler A. Improved tools for assessing long-term indoor and outdoor exposures in epidemiological studies of allergy and asthma. Presented at AllerGen 5th Annual Conference, Quebec City, Feb 2010. Overview and description of CMP-1 study.
  6. Urch B, Speck M, Scott J, Ewaze J, Brook JR, Gold D, Behbod B, Silverman F. Associations between inhaled endotoxin/β-D-glucan levels and airway/systemic neutrophils after controlled exposures to coarse and fine particles: effects of atopy on responses. Presented at 5th Annual AllerGen conference, Quebec City, 2010.
  7. Allen R, Curran J, Brook J, Takaro T, Wheeler A, Jiang Z, Grgicak-Mannion A, Speck M. An assessment of hopanes in settled house dust as indicators of exposure to traffic-related air pollution in Windsor, Ontario. Oral presentation, Annual Northwest International Section (PNWIS) Conference (Air & Waste Management Association (A&WMA), University of Montana in Missoula), Nov 2010
  8. Curran J, Brook J, Takara T, Wheeler A, Jiang Z, Grgicak A, Speck M, Ryan A. An assessment of hopanes in settled dust and air as indicators of exposure to traffic-related air pollution in Windsor, Ontario. Oral presentation, Annual UBC & University of Washington Environmental Health Conference, Semiahmoo, Washington, Jan 2011.
  9. Sbihi H, Allen R, Takaro T, Brook J, Brauer M. Estimating the variability of endotoxin, (1,3)-β-D-glucan, and hopanes in repeated samples of settled house dust. Presented at 6th Annual AllerGen conference, Vancouver, 2011
  10. Curran J, Brook J, Takara T, Wheeler A, Jiang Z, Grgicak-Mannion A, Speck M, Ryan A. An assessment of hopanes in settled dust and air as indicators of exposure to traffic-related air pollution in Windsor, Ontario. Poster presentation, 6th Annual AllerGen Research Conference, Vancouver, Feb 2011.
  11. Chaudhuri SR, Mukwedya E, Verkoeyen S, Diamond M. Indoor measurements and multimedia modeling of phthalates: Toronto Intensive (TI) homes. Presented at 7th Annual AllerGen conference, Toronto, 2012. Summary of findings from the "Toronto Intensive" study.
  12. Chaudhuri SR, Mukwedya E, Verkoeyen S, Speck M, Diamond M, Takaro T, Maclean K, Brook J, Jiang Z, Wheeler A. Indoor measurements and multimedia modeling of phthalates: Toronto Intensive (TI) homes. Poster presentation at International Council Chemical Associations-LRI and Health Canada Workshop: Advancing Exposure Science to improve Chemical Safety, Quebec City, June 2011. Summary of findings to date from the "Toronto Intensive" study.
  13. Takaro TK, Miller G, Shu H, McLean K, Kollmann TR, Fortuno III ES, Turvey S. Peri-natal environmental exposures and IL-6 measured in cord blood: Early expression of the hygiene hypothesis? Am J Respir Crit Care Med 2012;185:A2221. Presented at ATS 2012.

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