EXPECTED OUTCOME = Greater Understanding of the Root causes of Allergy and Asthma
The CHILD platform will be relevant to many different health researchers and disciplines, and to policy makers with respect to environment and health, including the impact of chronic diseases and exposures on the healthcare burden in Canada.
The CHILD birth cohort study is generating important new public health and policy information to examine the origins of allergy, asthma and associated environmental, nutritional and genetic triggers, from pregnancy and throughout childhood. The goal of the CHILD Study is to reveal the causes of allergic diseases through research into the health consequences of exposure to environmental triggers of allergy in the home environment and even during pregnancy. CHILD will deliver valuable data on pregnant mothers' exposures to allergenic food components, pollens, infections, pollutants, toxicants and psychosocial stress.
Data are highly relevant to several government agencies including Canadian Mortgage Housing Corporation (CMHC), Health Canada, Environment Canada, Public Health Agency of Canada (PHAC), and Federal and Provincial Ministries of Health, Environment and Science and Technology. Pharmaceutical companies are also interested in better characterization of allergy and asthma patients, and thus are interested in the CHILD Study results to inform their ability to target and evaluate new drugs.
CHILD will have a direct impact on public health-based prevention strategies for asthma and allergic diseases, environmental exposure regulations and policies, safe home product standards and regulations, food safety regulations and policies, urban planning and home design, maternal-child health in Canada and globally, prenatal care (diet, nutrition) guidelines, pediatric allergy and asthma guidelines, and novel therapeutic targets for drug discovery and exposure modulation. CHILD data and biological samples analyzed through collaboration with Health Canada and AllerGen NCE have already provided unique Canadian data on phthalate levels in house dust and in urine in infancy and early childhood. Such information will help guide federal policy on the use of chemicals in products and materials.
Impact of the CHILD Study
• Public health-based prevention strategies for asthma & allergic diseases
• Environmental exposure regulations & policies
• Safe home product standards & regulation
• Food safety regulations & policies
• Personalized healthcare
• Urban planning & home design
• Maternal-child health in Canada & globally
• Prenatal care (diet, nutrition) guidelines
• Pediatric allergy & asthma guidelines
• Novel therapeutic targets for drug discovery & exposure modulation
• Medical and allied heathcare professional education curricula
Canadian Birth Cohort Capacity building - Highly Qualified Personnel:
The CHILD Study has been and will continue to be instrumental in building capacity in several realms: mentoring young investigators, developing novel investigational procedures and preparing and validating Standard Operating Procedures (SOPs) for many aspects of the study. Many junior faculty members have been mentored through the initiation of the CHILD Study, maintaining and expanding their research interests in asthma and allergy. Each of these site leaders has received highly competitive salary awards for work within the CHILD Study.
Development of Standard Operating Procedures (SOPs) for environmental assessment has brought together environmental scientists, clinicians and basic scientists.
The comprehensive datasets and biological samples in the CHILD Study will provide a resource for students, clinical trainees and colleagues across disciplines to explore hypotheses and gain research experience. With access to high quality data and the potential for rapid publications, CHILD will provide a unique research experience for researchers and clinicians considering a science career.